Grants Funded Archive

The Oxalosis and Hyperoxaluria Foundation (OHF) is proud to be the largest nonprofit provider of grants for hyperoxaluria research in the world. Since our founding, The OHF has raised and committed more than $40 million for hyperoxaluria research, and has funded over 60 grants. Learn more about our early grants here and visit our Grants & Funding page for more information.

2011 Research Grants

• HDAd-mediated gene therapy for primary hyperoxaluria type 1 Nicola Brunetti-Pierri, MD Fondazione Telethon Rome, Italy
• Phenotypic changes associated with PH3 Ross P. Holmes, PhD Wake Forest University Health Sciences Winston-Salem, NC
• Biochemical and structural studies of variant forms of KHGA identified in type III primary hyperoxaluria W. Todd Lowther, PhD Wake Forest University Health Sciences Winston-Salem, NC

2010 Research Grants

• Probiotic Treatment of Primary Hyperoxaluria Marguerite Hatch, PhD University of Florida Gainesville, Florida
• Patient-specific pluripotent cells to derive hepatocytes for treating Primary Hyperoxaluria-1 Namita Roy-Chowdury, PhD Albert Einstein College of Medicine of Yeshiva University Bronx, New York

2009 Research Grants

• Genetic Studies into atypical hyperoxaluria Robert Kleta, MD, PhD, FASN, FACMG University College London London, United Kingdom
• Human KHGA: a novel target for the treatment of hyperoxaluria W. Todd Lowther, PhD Wake Forest University Health Sciences Winston-Salem, North Carolina
• Towards the pharmacological treatment of primary hyperoxaluria: multiply-transformed CHO cells as a model system Christopher J. Danpure, BSc PhD FMedSci University College London London, United Kingdom
  • Final Report: Towards the pharmacological treatment of primary hyperoxaluria: multiply-transformed CHO cells as a model system

2008 Research Grants

• Molecular insights into Primary Hyperoxaluria Type 1 Carla Voltattorni, PhD University of Verona Verona, Italy
  • Final Report: Molecular Insights into Primary Hyperoxaluria Type I
• Use of differential scanning fluorometry to identify ligands that stabilize AGT Chandra Tucker, PhD University of Duke Durham, North Carolina
  • Final Report: Use of differential scanning fluorometry to identify ligands that stabilize AGT
• Liver Cell Transplantation for Primary Hyperoxaluria Namita Roy-Chowdury, PhD Albert Einstein College of Medicine of Yeshiva University Bronx, New York
  • Final Report: The Utility of Oxalobacter in Enhancing Enteric Oxalate Excretion in Primary Hyperoxaluria Type 1

2007 Research Grants

• The Utility of Oxalobacter in Enhancing Enteric Oxalate Excretion in Primary Hyperoxaluria Type 1 Marguerite Hatch, PhD University of Florida Gainesville, Florida
  • Final Report: The Utility of Oxalobacter in Enhancing Enteric Oxalate Excretion in Primary Hyperoxaluria Type 1

2006 Research Grants

• Identification and characterization of pharmacological chaperones for AGT Chandra Tucker, PhD Duke University Durham, North Carolina
  • Final Report: Identification and Characterization of Pharmacological Chaperones for AGT
• Mutation-Specific Correction of Aberrant AGT Phenotypes in Transgenic Knockout Mice Eduardo Salido, MD, PhD Hospital Universitario Canarias / FRC Investigacion Spain
  • Final Report: Mutation-Specific Correction of Aberrant AGT Phenotypes in Transgenic Knockout Mice

2005 Research Grants

• Regulation of Renal Epithelial Cell Surface Calcium Oxalate Crystal Binding Molecule Vivek Kumar, PhD Mayo Clinic Rochester, Minnesota
  • Final Report: Regulation of Renal Epithelial Cell Surface Calcium Oxalate Crystal Binding Molecules”
• Hyaluronan and crystal retention Carl F. Verkoelen, PhD Erasmus Medical Center Rotterdam Rotterdam, The Netherlands

2004 Research Grants

• An investigation into the relationship between in vitro stone growth rate, oxalate and crystal size distribution John P. Kavanagh, PhD South Manchester University Hospitals Trust Manchester, England
  • Final Report: An investigation into the relationship between in vitro stone growth rate, oxalate and crystal size distribution
• Glycolate Oxidase Inhibition and the Treatment of Primary Hyperoxaluria Type 1 Ross Holmes, PhD Wake Forest University Health Sciences Winston-Salem, North Carolina
  • Final Report: Glycolate Oxidase Inhibition and the Treatment of Primary Hyperoxaluria Type 1

2003 Research Grants

• Establish A Clinical Center for Primary Hyperoxaluria Dawn S. Milliner, MD Mayo Foundation Rochester, Minnesota
• mRNA Expression of Renal Oxalate Transporters in Hyperoxaluria Mike L. Green, PhD University of Florida Gainesville, Florida

2002 Research Grants

• The Role of Tubule Epithelial Cell Pericellular Matrix Formation in the Retention of Calcium Oxalate Crystals Carl Verkoelen, PhD Erasmus Medical Center Rotterdam Rotterdam, The Netherlands
  • Final Report: The Role of Tubule Epithelial Cell Pericellular Matrix Formation in the Retention of Calcium Oxalate Crystals
• Towards a Better Understanding of the Metabolic Profile of the Hyperoxalurias Gill Rumsby, PhD, MRCPath University College London Hospitals London, England
• AGT Structure, Folding and Stability: Drug-Induced AGT Stabilization as a Treatment for Primary Hyperoxaluria Type 1 Christopher Danpure, BSc, PhD University College London London, England
  • Second Year Report: AGT Structure, Folding and Stability
  • Final Report: AGT Structure, Folding and Stability

2001 Research Grants

• Renal Oxalate Secretion And Proximal Tubule Injury
• Intracellular Oxalate Concentration: Isotopic And Fluorometric Determination
• Expressions And Characterization Of Oxalate Decarboxylase. A Potential Therapeutic/Prophylactic Agent For Hyperoxaluria

Final Reports

• Renal Oxalate Transport In An Animal Model Of Hyperoxaluria
• Genetic Analysis Of Primary Hyperoxaluria Type 2
• Calcium Oxalate Crystal Nucleation Onto Kidney Cells

 2000 Research Grants

• Structure of AGT and the Rational Search for Hyperactive AGT Variants
• Characterisation of Human Aglycolate Oxidase and Investigation of its Possible Role in Atypical Primary Hyperoxaluria
• Alanine-Glyoxylate Aminotransferase Deficient Mouse as Model for Gene Therapy of Primary Hyperoxaluria

  1999 Research Grants

• Renal Oxalate Transport in an Animal Model of Hyperoxaluria
• The Genetic Basis of PH2
• Elimination of Oxalate in Hyperoxaluric Conditions and Renal Failure
• Calcium Oxalate Crystal Nucleation onto Renal Cells

  1998 Research Grants

• Investigations into the Phenotype and Genotype of Atypical Primary Hyperoxaluria

  1997 Research Grants

• Treatment of PH1 with OTZ